Wydawnictwo Medyczne Mediton

Under the scientific patronage of

the Polish Society of Audiology and Phoniatrics


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Tissue engineering techniques in repairing of tympanic membrane perforations
Maria Makuszewska 1/, Magdalena Sokołowska 2/, Bożena Skotnicka 3/
  • 1/ Oddział Otolaryngologii, Wojewódzki Szpital Zespolony im. J. Śniadeckiego w Białymstoku
  • 2/ Zakład Patologii Ogólnej i Doświadczalnej, Uniwersytet Medyczny w Białymstoku
  • 3/ Klinika Otolaryngologii Dziecięcej, Uniwersytet Medyczny w Białymstoku

Tissue engineering combines the principles of engineering and life sciences to develop biological materials that substitute or restore the continuity and function of tissues and organs. This requires the synergistic control of the three components of this process: stem or somatic cells), proper matrix to support the proliferating cells, and inducing factors. This article reviews recent papers on those techniques used to induce tympanic membrane healing. The experiments with stem cells did not show their advantage over the cells of endogenous origin in the tympanic membrane healing process. However, many supporting materials, such as extracellular allo- and xenogenic matrices, collagen, silk fibroin or chitosan, have proved their biocompatibility, nontoxicity and nonimmunogenicity, as well as and suitable mechanical characteristics. Hialuronic acid has found practical application in the dressings used after otological surgery to accelarate the healing of tympanic membrane. Although growth factors tend to enhance the healing of tympanic membrane perforations, further studies are needed to determine which of them are most appropriate.

Otorynolaryngologia vol 14. no 1. Marchpages: from 1to 9
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